Diffuse Large B-cell Lymphoma Presented as Bone Lesions. a Study of 21 Cases and Review of the Literature

No1, 2013 Молекулярная медицина Primary bone lymphoma is suggested when the patient remains free of extraskeletal disease for 6 months after diagnosis, it was first described by Oberling in 1928. Parker and Jackson in 1939 published their series under the designation «reticulum cell sarcoma of bone» and established primary bone lymphoma as a distinct entity. For several decades the lesion was considered to be of lymphoid nature and B-cell origin in the majority of cases [1, 2, 13]. Most primary bone lymphomas have similar morphology composed of large centroblasric cells. Presence of multilobated nuclei is common, the lesion is usually characterized by prominent sclerosis and classified as diffuse large B-cell lymphoma (DLBCL) in the WHO classification of malignancies [4]. Most primary bone lymphomas arise de novo with no evidence of underlying low-grade lymphoproliferative disorder or preexisting small B-cell proliferation. It has been hypothesized that centroblastic and immunoblastic morphologic variants of DLBCL might reflect germinal center (GC) and postgerminal center (post-GC) derivation of the tumor [14]. The rare occurrence of primary bone lymphoma make it difficult to recognize, the differential diagnosis include major list of small cell malignancies of bone as well as osteomyelitis and Langerhans cell histiocytosis [12]. In this report we studied 21 cases of primary DLBCLs presenting with bone involvement. All secondary cases of bone lymphoma were excluded. The tumors were subclassified © Коллектив авторов, 2013 УДК 616.71-006.441.04-091.8